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Ac-VEID-AMC

ALX-260-064

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Caspase-6 substrate

Fluorogenic substrate for caspase-6 (K_m=30µML, K_cat/Km=168000M^-1se^c-1) and related cysteine proteases. Sequence is based on lamin A site of cleavage. Ex.:340-360nM, Em.:440-460nm.

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Product Details

Alternative Name	Caspase-6 substrate (fluorogenic)
Appearance	White to off-white powder.
CAS	219137-97-0
Formula	C₃₂H₄₃N₅O₁₁
MW	673.7
Peptide Content	70-90%
Purity	≥95% (HPLC)
Sequence	Ac-Val-Glu-Ile-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
Solubility	Soluble in DMSO; dilute with distilled water or buffer; also soluble in phosphate buffer, pH 7.5.
Technical Info / Product Notes	AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6: E.S. Okerberg, et al.; Biochemistry 58, 5320 (2019), Abstract
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis: D.J. MacPherson, et al.; J. Biol. Chem. 294, 71 (2018), Abstract
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding: K.B. Dagbay, et al.; J. Biol. Chem. 292, 4885 (2017), Abstract — Full Text
Purification and catalytic properties of human caspase family members: M. Garcia-Calvo, et al.; Cell Death Differ. 6, 362 (1999), Abstract
Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis: L.M. Martins, et al.; J. Biol. Chem. 272, 7421 (1997), Abstract — Full Text
Apoptosis by death factor: S. Nagata; Cell 88, 355 (1997), Abstract
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997), Abstract — Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract — Full Text
Cleavage of lamin A by Mch2alpha but not CPP32: multiple interleukin 1beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis: A. Takahashi, et al.; PNAS 93, 8395 (1996), Abstract
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32: S.M. Srinivasula et al.; J. Biol. Chem. 271, 27099 (1996), Abstract

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Ac-VEID-AMC

ALX-260-064

Product Details

Handling & Storage

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