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Ac-VEID-AFC

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Caspase-6 inhibitor

Fluorogenic substrate for caspase-6 (Km=30μM; Kcat/Km=168000 M-1sec-1) and related cysteine proteases. Sequence is based on lamin A site of cleavage.

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Alternative Name	Caspase-6 substrate (fluorogenic)
Formula	C₃₂H₄₀F₃N₅0₁₁
MW	727.7
Purity	≥98% (HPLC)
Sequence	Ac-Val-Glu-Ile-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Solubility	Soluble in DMSO or dimethyl formamide.
Technical Info / Product Notes	AFC has an excitation maximum of 400nm and an emission maximum of 505nm.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes: F. Anson, et al.; JACS Au 1, 1240 (2021), Abstract
Identification of Allosteric Inhibitors against Active Caspase-6: A. Tubelvicuite-Aydin, et al.; Sci. Rep. 9, 5504 (2019), Abstract — Full Text
Organ specific alteration in caspase expression and STK3 proteolysis during the aging process: M. Lessard-Beaudoin, et al.; Neurobiol. Aging 47, 50 (2016), Application(s): Caspase activity assays, Abstract — Full Text

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