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Ac-VDVAD-CHO

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Caspase-2 inhibitor

Potent, reversible aldehyde inhibitor of caspase-2 (K_i=3.5nM). Preferred cleavage sequence for caspase-2.

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Alternative Name	Caspase-2 inhibitor (aldehyde)
CAS	194022-51-0
Formula	C₂₃H₃₇N₅O₁₀
Formulation	Lyophilized.
MW	543.6
Peptide Content	70-90%.
Purity	≥94% (HPLC)
Sequence	Ac-Val-Asp-Val-Ala-Asp-CHO
Solubility	Soluble in DMSO (100mM, 54.4mg/ml) or buffer (pH 7-7.5).

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A Cell-Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer-Specific Synthetic Lethality: Son, S. H., Kim, M. Y., et al.; Adv. Sci. (Weinh.) 10, e2305096 (2023), Abstract
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997), Abstract — Full Text

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