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Ac-VDVAD-AMC

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Caspase-2 substrate

Fluorogenic substrate for caspase-2. Preferred cleavage site for caspase-2 (K_m=80μM).

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Alternative Name	Caspase-2 substrate (fluorogenic)
Appearance	White to off-white powder.
Formula	C₃₃H₄₄N₆O₁₂
MW	716.8
Peptide Content	75-95%
Purity	≥98% (HPLC)
Sequence	Ac-Val-Asp-Val-Ala-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
Solubility	Soluble in DMSO (100mM). Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES).
Technical Info / Product Notes	AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine: Søfteland, J. M., Bagge, J., et al.; Am. J. Transplant. 21, 2220 (2021), Abstract
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging: K. Vorobej, et al.; Exp. Gerontol. 101, 69 (2017), Abstract
Effect of mitochondrial fission inhibition on C2C12 differentiation: D. Bloemberg, et al.; Data Brief 7, 634 (2016), Application(s): Caspase activity, Abstract — Full Text
CD 95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes: T. Hieronymus, et al.; Cell Death Differ. 7, 538 (2000), Abstract
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997), Abstract — Full Text

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