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Ac-VDVAD-AFC

ALX-260-112

  • ALX-260-112-M005   —   5 mg
    $303.00
  • ALX-260-112-M010   —   10 mg
    $552.00

Fluorogenic substrate for caspase-2; similar to Ac-VDVAD-AMC but the AFC fluorophore has a greater Stokes’ shift upon cleavage. VDVAD has been found to be a preferred cleavage site for caspase-2 (Ich-1L). Increases in Ac-VDVAD-AFC cleavage correlated with losses in procaspase-2 (conversion to active caspase-2) in human neuroblastoma lines induced to apoptosis with C2-ceramide and NO.

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Regulatory Status

RUO – Research Use Only

Last modified: May 29, 2024