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Fluorogenic substrate for caspase-2; similar to Ac-VDVAD-AMC but the AFC fluorophore has a greater Stokes’ shift upon cleavage. VDVAD has been found to be a preferred cleavage site for caspase-2 (Ich-1L). Increases in Ac-VDVAD-AFC cleavage correlated with losses in procaspase-2 (conversion to active caspase-2) in human neuroblastoma lines induced to apoptosis with C2-ceramide and NO.
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| Regulatory Status |
RUO – Research Use Only |
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