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Ac-LEVD-AMC

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Caspase-4 substrate

Fluorogenic substrate for caspase-4.

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Alternative Name	Caspase-4 substrate (fluorogenic)
Appearance	White to off-white powder.
Formula	C₃₂H₄₃N₅O₁₁
MW	673.7
Peptide Content	75-95%
Purity	≥99% (HPLC)
Sequence	Ac-Leu-Glu-Val-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
Solubility	Soluble in DMSO. Dilute with distilled water or buffer, pH 7.5.
Technical Info / Product Notes	AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1: Yang, D., Cahoon, J. G., et al.; bioRxiv , (2024)
Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation: H. Ahn, et al.; Antioxidants 11, 1923 (2022), Abstract
Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure: Xu, W. F., Zhang, Q., et al.; Acta Pharmacol. Sin. 42, 68 (2021), Abstract
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract — Full Text

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