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Ac-LEHD-CHO

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Caspase-9 inhibitor

Reversible aldehyde inhibitor of caspase-9 and related cysteine proteases. Sequence is from combinatorial experiments.

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Alternative Name	Caspase-9 inhibitor (aldehyde)
Appearance	Lyophilized.
Formula	C₂₃H₃₄N₆O₉
MW	538.6
Peptide Content	≥65%
Purity	≥95%
Sequence	Ac-Leu-Glu-His-Asp-CHO
Solubility	Soluble in water or DMSO. Further dilute with buffer, pH 7.5.

Use/Stability	As indicated on product label or CoA when stored as recommended. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only amount needed at a time to avoid decomposition in solution.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells: M. Martinez-Castillo, et al.; Oncol. Lett. 15, 6777 (2018), Abstract — Full Text
Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells: A.Y. Jong, et al.; J. Extracell. Vesicles 6, 1294368 (2017), Abstract — Full Text
Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R531 (2011), Abstract — Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract