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Ac-IETD-pNA

ALX-260-045

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Caspase and granzyme substrate

Chromogenic substrate for caspase-6, -8 and granzyme B. Also a substrate for caspase-10. Similar to Ac-IETD-AMC and Ac-IETD-AFC but cleavage is monitored colorimetrically by absorbance at 405 nm.

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Product Details

Alternative Name	Caspase-8 substrate (chromogenic), Granzyme B substrate (chromogenic)
Appearance	White to yellow powder.
Formula	C₂₇H₃₈N₆O₁₂
Formulation	Lyophilized.
MW	638.6
Peptide Content	70-90%
Purity	≥95% (HPLC)
Sequence	Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline)
Solubility	Soluble in DMSO. Dilute with buffer, pH 7.0-7.5.
Technical Info / Product Notes	λmax of pNA is 400nm.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cardioprotective effects of Prolame and SNAP are related with nitric oxide production and with diminution of caspases and calpain-1 activities in reperfused rat hearts: N.G. Roman-Anguiano, et al.; PeerJ 7, e7348 (2019), Abstract — Full Text
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes: C.A. Belmokhtar, et al.; J. Biol. Chem. 278, 29571 (2003), Abstract — Full Text
Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells: S.H. Kwon, et al.; J. Biol. Chem. 277, 2073 (2002), Abstract — Full Text
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract — Full Text
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta, et al.; J. Biol. Chem. 272, 1965 (1997), Abstract
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994), Abstract

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Ac-IETD-pNA

ALX-260-045

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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