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Ac-IETD-CHO

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Caspase and granzyme inhibitor

Reversible inhibitor of caspase-6, -8 and granzyme B. Also inhibits caspase-10.

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Alternative Name	Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde)
CAS	191338-86-0
Formula	C₂₁H₃₄N₄O₁₀
Formulation	Lyophilized.
MW	502.5
Peptide Content	70-90%
Purity	≥96% (HPLC)
Sequence	Ac-Ile-Glu-Thr-Asp-CHO
Solubility	Soluble in distilled water at 10 mg/mL and in DMSO at 1 mg/mL.

Use/Stability	As indicated on product label or CoA when stored as recommended. Use always fresh solutions.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract — Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract

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