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Ac-IETD-AMC

ALX-260-042

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Caspase and granzyme substrate

Fluorogenic substrate for caspase-6 and -8 and granzyme B. Also a substrate for caspase-10.

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Product Details

Alternative Name	Granzyme B substrate (fluorogenic), Caspase-8 substrate (fluorogenic)
Appearance	White to off-white powder.
Formula	C₃₁H₄₁N₅O₁₂
MW	675.7
Peptide Content	70-90%
Purity	≥97% (HPLC)
Sequence	Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
Solubility	Soluble in DMSO. Dilute with buffer, pH 7.5.
Technical Info / Product Notes	AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Involvement of Bid in the crosstalk between ferroptotic agent-induced ER stress and TRAIL-induced apoptosis: J.H. Kim, et al.; J. Cell. Physiol. 237, 4180 (2022), Abstract
C33-A cells transfected with E6*I or E6*II the short forms of HPV-16 E6, displayed opposite effects on cisplatin-induced apoptosis: C.E. Vaisman, et al.; Virus Res. 247, 94 (2018), Abstract
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging: K. Vorobej, et al.; Exp. Gerontol. 101, 69 (2017), Abstract
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC8: N. Van Opdenbosch, et al.; Cell Rep. 21, 3427 (2017), Abstract — Full Text
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing: C. Lawlor, et al.; PLoS One 11, e0149167 (2016), Application(s): Caspase activity assays, Abstract — Full Text
Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway: Y. Lu, et al.; Int. J. Mol. Sci. 17, E775 (2016), Application(s): Caspase activation by Ru complexes, Abstract — Full Text
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway: Vondálová Blanárová, O., Jelínková, I., et al.; Carcinogenesis 32, 42 (2011), Abstract
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004), Abstract
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta, et al.; J. Biol. Chem. 272, 1965 (1997), Abstract
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract

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