AMPIVIEW® RNA probes
Enabling Your Projects 
GMP Services
Bulk Solutions
Research Travel Grant
Have You Published Using an Enzo Product?
Caspase-3 inhibitor
Highly specific, potent and reversible inhibitor of caspase-3. Ki<1nM for purified caspase-3. IC50=0.2nM for PARP cleavage in cultured human osteosarcoma cell extracts. In contrast, the caspase-1 (ICE) specific inhibitor YVAD-CHO has a Ki=12µM for caspase-3 and IC50>10µM for PARP cleavage in osteosarcoma cell extracts. The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.
Shipping: Available products typically ship within 24/48h, via priority shipping.
Do you need support? Contact Customer Service or Technical Support.
Online Account
Access or Create Your Account
Product Details
| Alternative Name |
Caspase-3 inhibitor (aldehyde), Caspase-7 inhibitor (aldehyde) |
|---|---|
| CAS |
169332-60-9 |
| Formula |
C20H30N4O11 |
| Formulation |
Lyophilized. |
| MW |
502.5 |
| Peptide Content |
70-90%. |
| Purity |
≥95% (HPLC) |
| Reconstitution |
Add 0.2ml DMSO per 1mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material. |
| Sequence |
Ac-Asp-Glu-Val-Asp-CHO |
| Solubility |
Soluble in distilled water or DMSO. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C. Solutions are stable for at least 1 month when stored at -20°C in the dark and protected from moisture. |
|---|---|
| Handling |
Keep under nitrogen. Keep cool and dry. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response: Martinez-Turtos, A., Paul, R., et al.; Oncoimmunology 11, 2116844 (2022), Abstract
- Apical-to-basal graded ROS metabolism in intact Hydra leads to distinct levels of injury-induced ROS signaling in apical and basal regenerating tips: Suknovic, N. S., Reiter-Karam, S., et al.; bioRxiv , (2022)
- Promoted Click” SERS Detection for Precise Intracellular Imaging of Caspase-3″””: W. Zhu, et al.; Anal. Chem. 93, 4876 (2021), Abstract
- Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells; Journal of Innate Immunity: S. Surabhi, et al.; J. Innate Immun. 10, 1159 (2021), Abstract
- The Therapeutic Value of SC66 in Human Renal Cell Carcinoma Cells: M. Xu, et al.; Cell Death Dis. 11, 353 (2020), Abstract — Full Text
- Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep. 10, 21837 (2020), Abstract — Full Text
- Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms: Park, S. H., Baek, K. H., et al.; Cell Chem. Biol. 25, 1242 (2018), Abstract
- Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells: Demirel, I., Persson, A., et al.; Front. Cell. Infect. Microbiol. 8, 81 (2018), Abstract
- Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells: M. Martinez-Castillo, et al.; Oncol. Lett. 15, 6777 (2018), Abstract — Full Text
- Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding: K.B. Dagbay, et al.; J. Biol. Chem. 292, 4885 (2017), Abstract — Full Text
- Albumin-binding caspase-cleavable prodrug that is selectively activated in radiation exposed local tumor: S.W. Chung, et al.; Biomaterials 94, 1 (2016), Application(s): Cell culture, Abstract
- MicroRNAs in Hyperglycemia Induced Endothelial Cell Dysfunction: M. Silambarasan, et al.; Int. J. Mol. Sci. 17, 518 (2016), Application(s): Cell culture, Abstract — Full Text
- Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts: R. Ghosh, et al.; Int. J. Cardiol. 223, 923 (2016), Application(s): Measurement of Caspase 3 activity – mouse heart, liver, and kidney, Abstract
- Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells: Del Bello, B., Toscano, M., et al.; PLoS One 8, e57236 (2013), Abstract
- Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R531 (2011), Abstract — Full Text
- Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line: Colosetti, P., Puissant, A., et al.; Autophagy 5, 1092 (2009), Abstract
- Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells: C. Dai & S.B. Krantz; Blood 93, 3309 (1999), Abstract
- Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells: X.M. Zhang, et al.; Biochem. J. 340, 127 (1999), Abstract — Full Text
- Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract — Full Text
- A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract — Full Text
- CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis: J. Schlegel, et al.; J. Biol. Chem. 271, 1841 (1996), Abstract — Full Text
- Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996), Abstract
- ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis: D.W. Nicholson; Nature Biotechnol. 14, 297 (1996), Abstract
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract
- Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik et al.; Nature 371, 346 (1994), Abstract
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
Please enter the lot number as featured on the product label
SDS
Enzo Life Science provides GHS Compliant SDS
If your language is not available please fill out the SDS request form