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Ac-Arg-Leu-Arg-AMC

BML-AW9785

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This fluorogenic peptide is often the substrate of choice for assaying the trypsin-like activity of purified proteasomes. Benefits include a low K_m, high specific activity, and the fact that the substrate is cleaved exclusively at the R-AMC bond.

Several substrates with R-AMC scissile bonds can be used for assaying trypsin-like activity. One such substrate is Ac-Arg-Leu-Arg-AMC, which benefits from a low Km, high specific activity and the fact that it is cleaved exclusively at the R-AMC bond. This fluorogenic peptide is often the substrate of choice for assaying the trypsin-like activity of purified proteasomes.

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Product Details

Alternative Name	Ac-RLR-AMC
Appearance	Solid.
Formula	C₃₀H₄₆N₁₀O₆
Formulation	Lyophilized.
MW	642.7
Purity	≥97% (HPLC)
Sequence	Ac-Arg-Leu-Arg-AMC
Solubility	Soluble in DMSO, methanol or aqueous solutions.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Targeting AML dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor: B. Roux, et al.; Sci. Transl. Med. 13, eabg1168 (2021), Abstract
A Transgenic Mouse Model of Eccentric Left Ventricular Hypertrophy With Preserved Ejection Fraction Exhibits Alterations in the Autophagy-Lysosomal Pathway: K. Wenzel, et al.; Front. Physiol. 12, 614878 (2021), Abstract
Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects: Scott, M. R., Meador-Woodruff, J. H., et al.; Mol. Psychiatry 25, 776 (2020), Abstract
The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System: A.C.D. Fuchs, et al.; Structure 25, 834 (2017), Abstract — Full Text
Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy: J. Li, et al.; J. Mol. Cell. Cardiol. 102, 53 (2016), Abstract
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells: J. Dose, et al.; Free Radic. Biol. Med. 96, 264 (2016), Application(s): Hepatic proteasome activity, Abstract
Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure: D.S. Pitcher, et al.; EBioMedicine 2, 642 (2015), Application(s): Fluorescence, Abstract
BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch: M. Minoia, et al.; Autophagy 10, 1603 (2014), Abstract — Full Text
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract — Full Text
Importance of the proteosome’s different proteolytic sites and the efficacy of inhibitors varies with the protein substrate.: A.F. Kisselev, et al.; J. Biol. Chem. 281, 8582 (2006), Abstract

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Ac-Arg-Leu-Arg-AMC

BML-AW9785

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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