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Ac-Ala-Pro-Nle-Asp-OH

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Highly specific inhibitor of the caspase-like peptidic activity of the 20S proteasome.

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Appearance	Glassy lyophilized solid.
Formula	C₂₀H₃₂N₄O₈
MW	456.5
Purity	≥95% (Reverse-Phase HPLC)
Sequence	Ac-Ala-Pro-Nle-Asp-OH
Solubility	Soluble in water:acetonitrile containing 0.1% TFA (3:1) at a concentration of 1mg/mL.

Use/Stability	As indicated on product label or CoA when stored as recommended. Once dissolved use solutions immediately and do not store.
Handling	Do not add buffers containing free amino groups as these will react with the aldehyde moiety thus inactivating the compound.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.: Kisselev, A.F., Garcia-Calvo, M., Overkleeft, H.S., Peterson, E., Pennington, M.W., Ploegh, H.L., Thornberry, N.A. and Goldberg, A.L.; J Biol. Chem. 278, 35869-35877 (2003)

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