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The YVAD-CHO portion of this peptide is a highly-specific, potent (Ki=1 nM) and reversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE), whose sequence is based on the pre-interleukin-1β Asp-116 cleavage site for caspase-1. The sequence linked N-terminal to YVAD-CHO (residues 1-16) has been shown to enhance cell permeability. The efficacy of the resulting chimeric peptide, for caspase-1 inhibition, is unknown.
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| Regulatory Status |
RUO – Research Use Only |
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