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Ac-AAVALLPAVLLALLAPDEVD-CHO

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Caspase inhibitor

Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10.

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Alternative Name	Caspase-3 inhibitor (aldehyde)
Appearance	White to off-white powder.
Formula	C₉₄H₁₅₈N₂₀O₂₇
Formulation	Lyophilized. TFA salt.
MW	2000.4
Peptide Content	65-95%.
Purity	≥95% (HPLC)
Sequence	Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
Solubility	Soluble in DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	After dissolving, prepare aliquots and store at -20°C. Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity: S.C. Wright, et al.; J. Exp. Med. 186, 1107 (1997), Abstract
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: W. Nicholson, et al.; Nature 376, 37 (1995), Abstract
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase: M. Tewari, et al.; Cell 81, 801 (1995), Abstract

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