AAL-993

BML-EI367

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VEGFR inhibitor

Highly potent inhibitor of VEGFR-1 (IC₅₀=130nM), VEGFR-2 (IC₅₀=23nM) and VEGFR-3 (IC₅₀=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

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Product Details

Alternative Name	2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
Appearance	Pale yellow solid.
CAS	269390-77-4
Couple Target	VEGFR
Couple Type	Inhibitor
Formula	C₂₀H₁₆F₃N₃O
MW	371.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis: P. W. Manley, et al.; Biochim. Biophys. Acta 1697, 17 (2004), Abstract
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors: P. W. Manley, et al.; J. Med. Chem. 45, 5687 (2002), Abstract

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AAL-993

BML-EI367

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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