AA147

• GMP format available

AA147 is an endoplasmic reticulum (ER) proteostasis regulator. It activates the ATF6-dependent ER stress response and the NRF2 oxidative stress response, providing protection against oxidative damage in neuronal cells.

Key features and applications include:

• ER Proteostasis Regulation: Activates ATF6 and NRF2 pathways.
• Oxidative Stress Protection: Reduces reactive oxygen species (ROS) and protects against glutamate-induced cytotoxicity.
• Broad-Spectrum Antiviral Activity: Inhibits dengue and Zika virus infections in an ATF6-independent manner.

Relevant disease states include:

• Neurodegenerative Diseases: Potential therapeutic for conditions like ischemic stroke and Alzheimer’s disease.
• Multiple Sclerosis: Alleviates symptoms in experimental autoimmune encephalitis (EAE) models by reducing ER stress and oligodendrocyte loss.
• Viral Infections: Effective against dengue and Zika viruses.