A 83-01

A 83-01 is a TGFbeta receptor inhibitor found to suppress over-expression of pro-fibrogenic factors. When applied in concert with Y27632 and CHIR99021, A 83-01 treatment resulted in transformation of rat mature hepatocytes into proliferative bipotent cells. A study on a mouse model treated with A 83-01 resulted in decrease in cardiac fibrosis and increase in miocardial viability. Topical application of A 83-01 to second-degree burns in rat skin reduced wound contraction during healing without delaying the wound closure.