A-769662

• GMP format available

A-769662 is a potent activator of AMP-activated protein kinase (AMPK), with an EC50 of 0.8 µM in vitro. It specifically targets AMPK heterotrimers containing the β1 subunit.

Key features and applications include:

• High Selectivity: Selectively activates AMPK β1 subunit-containing heterotrimers.
• Potency: Demonstrates strong activation with an EC50 of 0.8 µM.
• Stimulate Fatty Acid Oxidation: Promotes fatty acid oxidation in various cell types.
• Inhibit Adipocyte Differentiation: Reduces differentiation of preadipocytes into adipocytes.
• Enhance Glucose Uptake: Increases glucose uptake in skeletal muscle cells.
• Promote Endothelial Cell Survival: Supports endothelial cell survival during metabolic stress.

Relevant disease states include:

• Type 2 Diabetes: Improves glucose homeostasis and reduces plasma glucose levels.
• Obesity: Inhibits adipogenesis, making it useful in obesity research.
• Metabolic Syndrome: Addresses key components of metabolic syndrome by activating AMPK.
• Cardiovascular Diseases: Enhances endothelial cell survival, which is beneficial in cardiovascular research.