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9-cis-Retinoic acid

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Retinoid X receptor ligand

A high affinity ligand for the retinoid X receptor (RXR). Destabilizes VDR-RXR heterodimer-DNA complex.

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Alternative Name	Alitretinoin
Appearance	Light yellow to orange crystalline powder.
CAS	5300-03-8
Couple Target	Retinoid X receptor
Couple Type	Ligand
Formula	C₂₀H₂₈O₂
MW	300.4
Purity	≥98% (UHPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Store tightly sealed in dark. Protect from light.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression: Nagiec, M. M., Skepner, A. P., et al.; PLoS One 10, e0120295 (2015), Abstract
Increased dietary intake of vitamin A promotes aortic valve calcification in vivo: Huk, D. J., Hammond, H. L., et al.; Arterioscler. Thromb. Vasc. Biol. 33, 285 (2013), Abstract
Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol: Zhang, J., Cai, S., et al.; Assay. Drug Dev. Technol. 9, 136 (2011), Abstract
Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers: B. Cheskis & L. P. Freedman; Mol. Cell. Biol. 14, 3329 (1994), Abstract — Full Text
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids: G. Allenby, et al.; Proc. Natl. Acad. Sci. USA 90, 30 (1993), Abstract — Full Text
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor: R. A. Heyman, et al.; Cell 68, 397 (1992), Abstract
9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha: A. A. Levin, et al.; Nature 355, 359 (1992), Abstract

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