Home Shop 8(S)-Hydroxyeicosa-5Z,9E,11Z,14Z-tetraenoic acid (HETE)

8(S)-Hydroxyeicosa-5Z,9E,11Z,14Z-tetraenoic acid (HETE)

BML-H008

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Activator of PKC and PPARα

Biosynthesis in human neutrophils, phorbol ester-treated mouse epidermis and by hepatic microsomal cytochrome P-450. Chemotactic for neutrophils. Activator of PPARα. Activates mouse skin protein kinase C (PKC).

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Product Details

Alternative Name	8(S)-HETE
CAS	98462-03-4
Couple Target	PKC, PPAR
Couple Type	Activator
Formula	C₂₀H₃₂O₃
Formulation	Liquid. In ethanol.
MW	320.5
Purity	≥99% (HPLC)
Technical Info / Product Notes	Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. For HPLC, aliquots of ethanol solutions should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans: Y. Guan, et al.; Am. J. Physiol. 273, F1013 (1997), Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu, et al.; J. Biol. Chem. 270, 23975 (1995), Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites: H.H. Lo, et al.; Lipids 29, 547 (1994), Abstract
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin: M.A, Hughes & A.R. Brash; Biochim. Biophys. Acta 1081, 347 (1991), Abstract

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8(S)-Hydroxyeicosa-5Z,9E,11Z,14Z-tetraenoic acid (HETE)

BML-H008

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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