8-pMeOPT-2′-O-Me-cAMP

Analogue of the natural signal molecule cyclic AMP in which the hydrogen in position 8 of the heterocyclic nucleobase is replaced by the lipophilic 4-methoxyphenylthio moiety. In addition, the ribose 2′- hydroxy group has been methylated.
Potent stimulator of exchange factors directly activated by cAMP (Epac or cAMP-GEF), a newly discovered receptor for cyclic AMP.
Since a free 2′-ribose hydroxyl group in cyclic AMP is essential for stimulation of cAMP-dependent protein kinase (PKA), the methylated structure of 8-pMeOPT-2′-O-Me-cAMP is an extremely poor PKA activator and allows for specific discrimination between both signalling pathways.
Its high lipophilicity ( > dibutyryl-cAMP), allows for good membrane permeability in most biosystems, and its increased resistance towards phosphodiesterases  prevents from rapid hydrolysis.