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8-Hydroxyguanosine

ALX-480-075

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Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.

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Product Details

Alternative Name	8-OHG
Appearance	White to off-white powder.
CAS	3868-31-3
Formula	C₁₀H₁₃N₅O₆
Identity	Determined by UV-VIS and ESI-MS.
MW	299.2
Purity	≥98% (HPLC)
Solubility	Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Guanosine and its modified derivatives are endogenous ligands for TLR7: T. Shibata, et al.; Int. Immunol. 28, 211 (2016), Abstract
Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes: M. Lodovici, et al.; Free Radic. Biol. Med. 28, 13 (2000), Abstract
Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication: M.L. Kuo, et al.; Mutat. Res. 413, 143 (1998), Abstract
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool: J.Y. Mo, et al.; PNAS 89, 11021 (1992), Abstract
8-Substituted guanosine and 2′-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985), Abstract

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8-Hydroxyguanosine

ALX-480-075

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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