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8-CPT-cAMP

BML-CN130

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PKA activator

A lipophilic, cell-permeable cAMP analog which activates cAMP- and cGMP-dependent protein kinase. More potent than cAMP and more resistant to phosphodiesterasese, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCI-cBIMPS (Prod. No. BML-CN135).

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Product Details

Appearance	White solid.
CAS	93882-12-3
Couple Target	PKA
Couple Type	Activator
Formula	C₁₆H₁₄CIN₅O₆PS . Na
MW	493.8
Purity	≥96% (HPLC)
Solubility	Soluble in water (25mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store as supplied (solid) at -20°C for 1 year. Once dissolved in water, it can be stored frozen at -20°C up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell: X. Liu, et al.; Cell Death Dis. 14, 142 (2023), Abstract
Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase: B. Zhou, et al.; Cell Rep. 37, 109785 (2021), Abstract
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis: M. Ploton, et al.; J. Hepatol. 69, 1099 (2018), Abstract
Glucagon-like peptide-1 Regulates Cholecystokinin Production in β-cells to Protect from Apoptosis: A.K. Linnemann, et al.; Mol. Endocrinol. 29, 978 (2015), Application(s): Cell Culture, Abstract — Full Text
Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model: Deng, G. H., Liu, J., et al.; J. Exp. Clin. Cancer Res. 33, 21 (2014), Abstract
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 616 (2011), Abstract — Full Text
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system: R.V. Schillace et al.; J. Immunol. 174, 6847 (2005), Abstract
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA): B.J. Connolly et al.; Biochem. Pharmacol. 44, 2303 (1992), Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger et al.; PNAS 89, 1031 (1992), Abstract
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3′,5′-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al; Biochem. J. 279, 521 (1991), Abstract

Last modified: May 29, 2024

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8-CPT-cAMP

BML-CN130

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