Home Shop 8-Bromoadenosine 3′,5′-cyclic Monophosphothioate, Rp-Isomer . sodium salt

8-Bromoadenosine 3′,5′-cyclic Monophosphothioate, Rp-Isomer . sodium salt

ALX-480-024

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PKA inhibitor

Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No. BML-CN135, and Prod. No. ALX-480-085). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No. BML-CN115).

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Product Details

Alternative Name	Rp-8-Br-cAMPS . Na, 8-Br-cAMPS . Na, Rp-isomer
Appearance	White to off-white powder.
CAS	129735-00-8
Couple Target	PKA
Couple Type	Inhibitor
Formula	C₁₀H₁₀BrN₅O₅PS . Na
Identity	Identity determined by MS and UV.
MW	423.2 . 23.0
Purity	≥99% (HPLC)
Solubility	250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway: G. Mottola, et al.; PLoS One 12, e0174936 (2017), Abstract — Full Text
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture: B.T. Gjertsen, et al.; J. Biol. Chem. 270, 20599 (1995), Abstract — Full Text
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase: A.C. Chao, et al.; EMBO J. 13, 1065 (1994), Abstract