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8-Bromo-cAMP

BML-CN115

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PKA activator

A cell-permeable cAMP analog which is more resistant to phosphodiesterases than cAMP and which preferentially activates cAMP-dependent protein kinase (PKA). Has increased metabolic stability and membrane permeability comapred with cAMP.

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Product Details

Appearance	White to grey powder
CAS	76939-46-3
Couple Target	PKA
Couple Type	Activator
Formula	C₁₀H₁₀BrN₅O₆P . Na
Identity	Determined by 1H-NMR, 31P-NMR, ESI-MS and UV.
MW	430.1
Purity	≥98% (HPLC)
Solubility	Soluble in water (100mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short: Andrews, C. S., Matsuyama, S., et al.; Sci. Rep. 6, 34445 (2016), Abstract
Hormone-induced 14-3-3γ adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells: Y. Aghazadeh et.al; J. Biol. Chem. 287, 15380 (2012), Application(s): Activation of cAMP-dependent protein kinase (PKA)., Abstract — Full Text
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs: Y.-J. Hei et al.; Mol. Pharmacol. 39, 233 (1991), Abstract
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3’,5’-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al.; Biochem. J. 279, 521 (1991), Abstract
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer Jr. & J.P. Miller; Life. Sci. 14, 1019 (1974), Abstract

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8-Bromo-cAMP

BML-CN115

Product Details

Handling & Storage

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