8-Br-2′-O-Me-cAMP

Analogue of the natural signal molecule cyclic AMP in which the hydrogen in position 8 of the heterocyclic nucleobase is replaced by bromine. In addition, the ribose 2′-hydroxy group has been methylated.
Potent stimulator of exchange factors directly activated by cAMP (Epac or cAMP-GEF), a newly discovered receptor for cyclic AMP. Since a free 2′-ribose hydroxyl group in cyclic AMP is essential for stimulation of cAMP-dependent protein kinase (PKA), the methylated structure of 8-Br-2′-O-Me-cAMP is an extremely poor PKA activator and allows for specific discrimination between both signalling pathways.