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7,7-Dimethyleicosadienoic acid

BML-EI112

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Phospholipase inhibitor

Non-metabolizable analog of arachidonic or eicosadienoic acid. Cell permeable. DEDA inhibits P388D₁ cell phospholipase A₂ (PLA₂) (IC₅₀=16 µM) and snake venom PLA₂ (IC₅₀=14 µM). It inhibits human recombinant sPLA₂ (IC₅₀=5.8 µM) selectively over cPLA₂. It is also a weak inhibitor of 5-lipoxygenase (IC₅₀=56 µM, RBL-l cells). Inhibits induction of the anti-viral state in human fibroblasts induced by interferon.

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Product Details

Alternative Name	DEDA
Appearance	Viscous colorless or pale yellow oil.
CAS	89560-01-0
Couple Target	Phospholipase
Couple Type	Inhibitor
Formula	C₂₂H₄₀O₂
MW	336.6
Purity	≥99%
Solubility	Soluble in 100% ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at 4°C for up to 1 year. Store solutions at -20°C for up to 6 months.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions 39, C39 (1993), Abstract
Effect of the phospholipase A2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts: C.A. Sargent, et al.; J. Pharmacol. Exp. Ther. 262, 1161 (1992), Abstract
Arachidonic acid regulates the binding of human interferon in human skin fibroblasts: S.D. Menon, et al.; Lipids 25, 321 (1990), Abstract
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide: M.D. Lister, et al.; J. Biol. Chem. 264, 8520 (1989), Abstract
Analogs of arachidonic acid methylated at C-7 and C-10 as inhibitors of leukotriene biosynthesis: N. Cohen, et al.; Prostaglandins 27, 553 (1984), Abstract

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7,7-Dimethyleicosadienoic acid

BML-EI112

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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