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7-Oxostaurosporine

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Apoptosis inducer. PKC inhibitor.

Antibiotic. Potent inhibitor of protein kinase C (PKC). Inhibits the cell cycle at the G2 stage.

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Alternative Name	Antibiotic BMY 41950, Antibiotic RK 1409, LCM76-L
Appearance	Yellow solid.
CAS	125035-83-8
Couple Target	PKC
Couple Type	Inhibitor
Formula	C₂₈H₂₄N₄O₄
MW	480.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, dimethyl formamide, methanol or 100% ethanol; slightly soluble in water.
Source	Isolated from Streptomyces sp. MST-AS5345.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity: H. Osada, et al.; J. Antibiot. 45, 189 (1992), Abstract
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure: H. Koshino, et al.; J. Antibiot. 45, 195 (1992), Abstract

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