7-CN-7-C-Ino

7-CN-7-C-Ino is a potent and highly specific activator of the cAMP-independent trypanosomal protein kinase A (in Trypanosoma brucei EC₅₀ 6.5 ± 4.6 nM on the purified holoenzyme, KD 8 ± 2 nM to the regulatory subunit PKAR) that has low toxicity in vivo. It was also described as a naturally occuring metabolite, called Jaspamycin, isolated from the marine sponge Jaspis splendens.