7-Cl-O-Nec1

Necrostatin-1 analogue with superior potency, selectivity and metabolic stability in blocking RIP1. 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1). 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1, no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice. 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.