AMPIVIEW® RNA probes
Enabling Your Projects 
GMP Services
Bulk Solutions
Research Travel Grant
Have You Published Using an Enzo Product?
NOS cofactor
Cofactor of nitric oxide synthases (NOS).
Shipping: Available products typically ship within 24/48h, via priority shipping.
Do you need support? Contact Customer Service or Technical Support.
Online Account
Access or Create Your Account
Product Details
| Alternative Name |
(6R)-BH4 . 2HCl, [6R-[6R*(1R*,2S*)]]-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone . 2HCl, Sapropterin . dihydrochloride |
|---|---|
| Appearance |
White to off-white powder. |
| CAS |
69056-38-8 |
| Formula |
C9H15N5O3 . 2HCl |
| MI |
14: 8368 |
| MW |
314.2 |
| Purity |
≥98% (HPLC) |
| Solubility |
Soluble in water (25mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for several years when stored at -20°C.Sensitive to oxidation, especially in neutral and alkaline solutions. Solutions must be stored at -20°C or colder immediately after preparation. Use oxygen free water with the lowest possible pH. Ascorbic acid, DTT, or other antioxidants may be added in order to increase stability. |
|---|---|
| Handling |
Hygroscopic. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Protective effects of (6R) 5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion induced suppression of reactive hyperemia in rat gingiva: Y. Tanaka, et al.; J. Clin. Biochem. Nutr. 58, 69 (2015), Abstract — Full Text
- Tetrahydrobiopterin and cytokines: E.R. Werner, et al.; Proc. Soc. Exp. Biol. Med. 203, 1 (1993), (Review), Abstract
- Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem. 268, 1842 (1993), Abstract — Full Text
- Regulation of the L-arginine-dependent and tetrahydrobiopterin- dependent biosynthesis of nitric oxide in murine macrophages: G. Schoedon, et al.; Eur. J. Biochem. 213, 833 (1993), Abstract
- Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages: N. Sakai and S. Milstien; BBRC 193, 378 (1993), Abstract
- Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem. 267, 25722 (1992), Abstract — Full Text
- Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor: P. Klatt, et al.; FEBS Lett. 305, 160 (1992), Abstract
- Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity: J.M. Hevel & M.A. Marletta; Biochemistry 31, 7160 (1992), Abstract
- Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages: R.A. Pufahl, et al.; Biochemistry 31, 6822 (1992), Abstract
- Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells: J.S. Pollock, et al.; PNAS 88, 10480 (1991), Abstract
- Brain nitric oxide synthase is a biopterin- and flavin-containing multi- functional oxido-reductase: B. Mayer, et al.; FEBS Lett. 288, 187 (1991), Abstract
- Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine: J. Giovanelli, et al.; PNAS 88, 7091 (1991), Abstract
- Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages: N.S. Kwon et al.; J. Biol. Chem. 264, 20496 (1989), Abstract
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
Please enter the lot number as featured on the product label
SDS
Enzo Life Science provides GHS Compliant SDS
If your language is not available please fill out the SDS request form