6BIO

ALX-430-156

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Inibitor of phosphoinositide-dependent kinase 1 and GSK

Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β) (IC₅₀=5nM). Maintains self-renewal and pluripotency in embryonic stem cells via activation of Wnt in vitro. Promotes proliferation and dedifferentiation in cardiomyocytes.

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Product Details

Appearance	Dark red solid.
CAS	667463-62-9
Couple Target	GSK, Phosphoinositide-dependent protein kinase
Couple Type	Inhibitor
Formula	C₁₆H₁₀BrN₃O₂
MW	356.2
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Adipose-derived mesenchymal stem cells promote salivary duct regeneration via a paracrine effect: S. Kang, et al.; J. Oral. Biosci. 65, 104 (2023), Abstract
Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL: Y.A. Albalawi, et al.; Viruses 14, 1469 (2022), Abstract
Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2: Yan, R., Zhu, H., et al.; Cell Rep. 38, 110319 (2022), Abstract
Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer: Qu, Y., Gharbi, N., et al.; PNAS 113, 9339 (2016), Abstract
GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2: Horbach, T., Chi, T. F., et al.; PLoS One 9, e107914 (2014), Abstract
Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production: A. Valerio, et al.; J. Neurochem. 116, 1148 (2011), Abstract
Anticancer effects and antimetastatic mechanisms of novel indirubin derivatives: C.A. Kressirer; , (2010), (PhD thesis), Full Text
Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover: R. Yasuhara, et al.; J. Biol. Chem. 285, 317 (2010), Abstract — Full Text
Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A: L. Martin, et al.; Brain Res. 1252, 66 (2009), Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007), Abstract