Home Shop 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

ALX-270-437

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SIRT inhibitor

Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC₅₀=98nM in vivo / IC₅₀=38nM in vitro; compared to hSIRT2: IC₅₀=19µM and hSIRT3: IC₅₀=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC₅₀>100µg). Inhibits the deacetylation of p53 (IC₅₀=1µM).

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Product Details

Alternative Name	EX-527
Appearance	White to light yellow powder.
CAS	49843-98-3
Couple Target	SIRT
Couple Type	Inhibitor
Formula	C₁₃H₁₃ClN₂O
Identity	Identity determined by 1H-NMR.
MW	248.7
Purity	≥95% (HPLC)
Purity Detail	Racemic mixture
Solubility	Soluble in DMSO (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 6 months when stored at -20°C in the dark.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392: F. De Bellis, et al.; Cancer Res. 74, 2328 (2014), Abstract
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism: M. Gertz, et al.; Proc. Natl. Acad. Sci. U S A. 110, E2772 (2013), Abstract — Full Text
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes: J.C. Milne, et al.; Nature 450, 712 (2007), Abstract
Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage: J.M. Solomon, et al.; Mol. Cell. Biol. 26, 28 (2006), Abstract
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1: A.D. Napper, et al.; J. Med. Chem. 48, 8045 (2005), Abstract

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6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

ALX-270-437

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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