Home Shop 5,8,11,14-Eicosatetraynoic acid

5,8,11,14-Eicosatetraynoic acid

BML-ET004

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Arachidonic acid uptake inhibitor

Inhibits arachidonic acid uptake. Inhibits cyclooxygenase (ID₅₀=8 µM) and all lipoxygenases (ID₅₀=10, 0.3, and 0.2 µM for 5-, 12- and 15-LO respectively) in whole cells. Inhibits PLA₂ and cytochrome P-450. Modulates Ca²⁺ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. PPAR agonist.

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Product Details

Alternative Name	ETYA
Appearance	Off-white solid.
CAS	1191-85-1
Couple Target	COX, Cytochrome P450, Lipoxygenase, PLA, PPAR
Couple Type	Activator, Inhibitor
Formula	C₂₀H₂₄O₂
MW	296.5
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, methanol, DMSO, acetone or acetonitrile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Make solutions fresh daily.
Handling	Protect from light and oxygen.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract — Full Text
Activation of TRPA1 by farnesyl thiosalicylic acid: M. Maher, et al.; Mol. Pharmacol. 73, 1225 (2008), Abstract
Effects of 5,8,11,14-eicosatetraynoic acid on thapsigargin-induced calcium entry, and intracellular pH in thyroid FRTL-5 cells: E. Ekokoski & K. Tornquist; Biochim. Biophys. Acta 1223, 274 (1994), Abstract
Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14- eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4: F. Ondrey, et al.; Cancer Res. 49, 1138 (1989), Abstract
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification: A.S. Taylor, et al.; Prostaglandins 29, 449 (1985), Abstract
The mechanism of inactivation of lipoxygenases by acetylenic fatty acids: H. Kühn, et al.; Eur. J. Biochem. 139, 577 (1984), Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med. 13, 53 (1984), Abstract
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC 114, 743 (1983), Abstract
Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites: E.Y. Chi, et al.; Lab. Invest. 47, 579 (1982), Abstract
Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes: G.M. Bokoch & P.W. Reed; J. Biol. Chem. 256, 4156 (1981), Abstract — Full Text

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5,8,11,14-Eicosatetraynoic acid

BML-ET004

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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