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5,8,11-Eicosatriynoic acid

BML-ET003

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Lipoxygenase inhibitor

Inhibits lipoxygenases (ID₅₀=3, 20 and 20µM for 5-, 12- and 15-LO respectively) selectively over cyclooxygenase (ID₅₀=50µM) in whole cells. Also inhibits hepatic glutathione S-transferase and leukotriene C₄ biosynthesis.

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Product Details

Alternative Name	ETI
Appearance	Off-white solid.
CAS	13488-22-7
Couple Target	GST, Lipoxygenase
Couple Type	Inhibitor
Formula	C₂₀H₂₈O₂
MW	300.4
Purity	≥98% (TLC)
Solubility	Soluble in ethanol (25mg/ml), DMSO (25mg/ml) or dimethyl formamide.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light and oxygen. Keep under inert gas.
Long Term Storage	+4°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death: R.G. Fred, et al.; Mol. Cell. Endocrinol. 414, 53 (2015), Application(s): Cell culture , Abstract
Inhibition of mammalian hepatic glutathione S-transferases by acetylenic fatty acids: K. Datta & A.P. Kulkarni; Toxicol. Lett. 73, 157 (1994), Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med. 13, 53 (1984), Abstract
Inhibition of leukotriene C and leukotriene D biosynthesis: L. Orning & S. Hammarstrom; J. Biol. Chem. 255, 8023 (1980), Abstract
Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid: S. Hammarstrom; Biochim. Biophys. Acta 487, 517 (1977), Abstract

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5,8,11-Eicosatriynoic acid

BML-ET003

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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