Home Shop 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

BML-EI231

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Casein kinase inhibitor

DRB is a potent and specific inhibitor of casein kinase II (CKII, IC₅₀~6 µM). It has been used to inhibit RNA polymerase II mediated-transcription which may be dependent on CKII and its interaction with ATF-1.

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Product Details

Alternative Name	DRB, 5,6-Dichlorobenzimidazole riboside
Appearance	White solid.
CAS	53-85-0
Couple Target	Casein kinase
Couple Type	Inhibitor
Formula	C₁₂H₁₂Cl₂N₂O₄
Identity	Determined by 1H-NMR.
MW	319.1
Purity	≥97% (TLC)
Solubility	Soluble in DMSO (20mg/ml), 100% ethanol, and dimethyl formamide (100mM).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Increased 14-3-3 phosphorylation observed in Parkinson’s disease reduces neuroprotective potential of 14-3-3 proteins: S.R. Slone, et al.; Neurobiol. Dis. 79, 1 (2015), Application(s): Cell Culture, Abstract
Histone hyperacetylation during SV40 transcription is regulated by p300 and RNA polymerase II translocation: L. Balakrishnan & B. Milavetz; J. Mol Biol. 371, 1022 (2007), Abstract — Full Text
RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells: R.H. te Poele, et al.; Oncogene 18, 5765 (1999), Abstract — Full Text
Copurification of casein kinase II with transcription factor ATF/E4TF3: T. Wada, et al.; Nucleic Acids Res. 24, 876 (1996), Abstract
Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB): C.E. Farin & L. Yang; Mol. Reprod. Dev. 37, 284 (1994), Abstract
Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II: R.O. Zandomeni; Biochem. J. 262, 469 (1989), Abstract
Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription: R. Zandomeni, et al.; J. Biol. Chem. 261, 3414 (1986), Abstract
Mechanism of action of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery: B. Mittleman, et al.; J. Mol. Biol. 165, 461 (1983), Abstract
Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription: R. Zandomeni, et al.; J. Mol. Biol. 167, 561 (1983), Abstract
Halobenzimidazole ribosides and RNA synthesis of cells and viruses: I. Tamm & P.B. Sehgal; Adv. Virus Res. 22, 187 (1978), Abstract

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5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

BML-EI231

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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