Home Shop 5-Nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione

5-Nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione

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NMDA receptor antagonist

Potent and selective NMDA receptor glycine site antagonist.

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Alternative Name	ACEA-1021
Appearance	Yellow powder.
CAS	153504-81-5
Couple Target	NMDA receptor
Couple Type	Inhibitor
Formula	C₈H₃Cl₂N₃O₄
MW	276.0
Purity	≥98% (TLC; elemental analysis)
Solubility	Soluble in DMSO or dilute aqueous base.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D- aspartate receptor glycine sites: R.M. Woodward, et al.; Mol. Pharmacol. 47, 568 (1995), Abstract
Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3- quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist: R.M. Woodward, et al.; J. Pharmacol. Exp. Ther. 275, 1209 (1995), Abstract
Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors: J.F.W. Keana, et al.; J. Med. Chem. 38, 4367 (1995), Abstract

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