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Thymidylate synthetase inhibitor
Potent antitumor agent. Inhibits thymidylate synthetase. Induces p53-dependent apoptosis.
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Product Details
| Alternative Name |
5-FU, 2,4-Dioxo-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione |
|---|---|
| Appearance |
White to off-white crystalline powder. |
| CAS |
51-21-8 |
| Couple Target |
Thymidylate synthetase |
| Couple Type |
Inhibitor |
| Formula |
C4H3FN2O2 |
| Identity |
Determined by IR. |
| MI |
14: 4181 |
| MW |
130.1 |
| Purity |
≥98% (HPLC) |
| RTECS |
YR0350000 |
| Solubility |
Soluble in DMSO (5mg/ml), dimethyl formamide (5mg/ml), methanol (1mg/ml) or hot water (1mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model: Nguyen, T. T. T., Tanaka, Y., et al.; Mol. Pharmacol. 103, 199 (2023), Abstract
- Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita: H. Tummala, et al.; Am. J. Hum. Genet. 109, 1472 (2022), Abstract
- A selective p53 activator and anticancer agent to improve colorectal cancer therapy: H. Ramos, et al.; Cell Rep. 35, 108982 (2021), Abstract
- PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al.; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract — Full Text
- Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets: Sahoo, S., Singh, P., et al.; BMC Cancer 15, 931 (2015), Abstract
- Omega-3 eicosapentaenoic acid decreases CD133 colon cancer stem-like cell marker expression while increasing sensitivity to chemotherapy: De Carlo, F., Witte, T. R., et al.; PLoS One 8, e69760 (2013), Abstract
- Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer: He, B. C., Gao, J. L., et al.; Mol. Pharmacol. 79, 211 (2011), Abstract
- 5-fluorouracil sensitivity and dihydropyrimidine dehydrogenase activity in advanced gastric cancer: T. Inada, et al.; Anticancer Res. 20, 2457 (2000), Abstract
- Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line: H. Takeda, et al.; Jpn. J. Cancer Res. 90, 677 (1999), Abstract
- Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells: S. Wadler, et al.; Biochem. Pharmacol. 55, 1353 (1998), Abstract
- Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity: D.M. Pritchard, et al.; Toxicol. Lett. 102, 19 (1998), Abstract
- Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells: K.H. Elstein, et al.; Toxicol. Appl. Pharmacol. 146, 29 (1997), Abstract
- Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis: J. Pressacco, et al.; Br. J. Cancer 72, 939 (1995), Abstract
- Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res. 14, 1027 (1994), Abstract
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