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5-Aminosalicylic acid

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NF-κB pathway inhibitor

Inhibits TNF-α regulated IκB degradation and NF-κB activation.

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Alternative Name	5-ASA, Mesalamine, 5-Amino-2-hydroxybenzoic acid
Appearance	White to light gray or light pink powder or crystalline solid.
CAS	89-57-6
Formula	C₇H₇NO₃
Identity	Determined by IR.
MI	14: 5904
MW	153.1
Purity	≥98% (TLC)
Solubility	Soluble in 1 M hydrochloric acid.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine: S. Liptay, et al.; Br. J. Pharmacol. 128, 1361 (1999), Abstract
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells: F. Yan & D.B. Polk; J. Biol. Chem. 274, 36631 (1999), Abstract — Full Text

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