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5-AIQ . hydrochloride

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PARP-1 inhibitor

Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier: J. Neuroinflammation; S. Rom, et al. 13, 254 (2016), Application(s): Cell culture with primary human monocytes from HIV-1/hepatitis B seronegative donors , Abstract — Full Text
Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis: B.D. Poole, et al.; Int. J. Med. Sci. 8, 88 (2011), Abstract — Full Text
Oocyte numbers in the mouse increase after treatment with 5-aminoisoquinolinone: a potent inhibitor of poly(ADP-ribosyl)ation: H. Qian, et al.; Biol. Reprod. 82, 1000 (2010), Abstract — Full Text
Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation: N.R. Jog, et al.; J. Immunol. 182, 7297 (2009), Abstract — Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury: S. Cuzzocrea, et al.; Biochem. Pharmacol. 63, 293 (2002), Abstract
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 130, 843 (2000), Abstract

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