4EGI-1

ALX-430-155

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eIF inhibitor

Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G).

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Product Details

Alternative Name	α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
Appearance	Brown solid.
CAS	315706-13-9
Couple Target	eIF
Couple Type	Inhibitor
Formula	C₁₈H₁₂Cl₂N₄O₄S
Identity	Determined by MS, IR.
MW	451.3
Purity	≥95% (TLC)
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR: S. Ivanov & C. Roy; Nat. Immunol. 14, 1219 (2013), Application(s): Analysis of mouse macrophages by WB, PCR, Abstract — Full Text
Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation: Fournier, M. J., Coudert, L., et al.; Mol. Cell. Biol. 33, 2285 (2013), Abstract
Spinal protein kinase M zeta underlies the maintenance mechanism of persistent nociceptive sensitization: M.N. Asiedu, et al.; J. Neurosci. 31, 6646 (2011), Abstract — Full Text
The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation: S. Fan, et al.; Neoplasia 12, 346 (2010), Abstract
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis: F. Grespi, et al.; Cell Death Differ. 17, 1672 (2010), Abstract — Full Text
IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex: O.K. Melemedjian, et al.; J. Neurosci. 30, 15113 (2010), Abstract — Full Text
Uncoupling stress granule assembly and translation initiation inhibition: S. Mokas, et al.; Mol. Biol. Cell 20, 2673 (2009), Abstract — Full Text
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G: N.J. Moerke, et al.; Cell 128, 257 (2007), Abstract

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4EGI-1

ALX-430-155

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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