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3,3’-Diindolylmethane

ALX-350-370

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Cytochrome P450 activator

Dimer of indole-3-carbinol (Prod. No. ALX-350-347). Anticancer and antineoplastic agent. Induces apoptosis in human cancer cells. Activator of cytochrome P450. Partial agonist of aryl hydrocarbon receptor (AhR).

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Product Details

Alternative Name	DIM
Appearance	White to light pink powder.
CAS	1968-05-4
Couple Target	Cytochrome P450
Couple Type	Activator
Formula	C₁₇H₁₄N₂
MW	246.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (200mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

3,3’-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol. 75, 1858 (2008), Abstract
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008), Abstract
Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett. 262, 153 (2008), Abstract
Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med. 13, 69 (2007), Abstract — Full Text
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003), Abstract — Full Text
3,3’-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica 28, 803 (1998), Abstract
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996), Abstract
3,3’-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC 228, 153 (1996), Abstract
The anticarcinogen 3,3′-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995), Abstract
Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992), Abstract

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3,3’-Diindolylmethane

ALX-350-370

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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