Home Shop 3-O-Methyl-Sphingomyelin

3-O-Methyl-Sphingomyelin

BML-SL225

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Sphingomyelinase inhibitor

3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (K_i=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase.

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Product Details

Appearance	White to off-white solid.
Couple Target	Sphingomyelinase
Couple Type	Inhibitor
Formula	C₃₂H₆₅N₂O₆P
Identity	Determined by NMR.
MW	604.8
Purity	≥98% (TLC)
Solubility	Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

ECM Modifications Driven by Age and Metabolic Stress Directly Promote Vascular Smooth Muscle Cell Osteogenic Processes: Whitehead, M., Faleeva, M., et al.; Arterioscler. Thromb. Vasc. Biol. 45, 424 (2025), Abstract
Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI: Kapustin, A., Tsakali, S. S., et al.; bioRxiv , (2023)
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling: A.N. Kapustin, et al.; Commun. Biol. 4, 1241 (2021), Abstract
Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition: Y. Chang, et al.; Int. J. Mol. Sci. 18, 2545 (2017), Abstract — Full Text
An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils: Sitrin, R. G., Sassanella, T. M., et al.; Am. J. Respir. Cell Mol. Biol. 44, 205 (2011), Abstract

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3-O-Methyl-Sphingomyelin

BML-SL225

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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