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3′-O-Ac-dCTP is an analogue of dCTP with blocked 3’-hydroxy function, which can be used as a transient, pH-sensitive chain terminator during DNA polymerization. The acetyl group of 3′-O-Ac-dCTP is sensitive towards alkaline conditions and can be easily split off at pH > 8 to allow further subsequent polymerization steps.
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RUO – Research Use Only |
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