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3-Methyladenine

BML-AP502

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PI3 kinase inhibitor

PI3 kinase inhibitor and a well-known inhibitor of autophagy. This compound has been shown to induce autophagy under nutrient-rich conditions as well as inhibiting starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase.

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Product Details

Alternative Name	6-Amino-3-methylpurine
Appearance	White solid.
CAS	5142-23-4
Couple Target	PI3 kinase
Couple Type	Inhibitor
Formula	C₆H₇N₅
Identity	Determined by NMR.
MW	149.2
Purity	≥98% (HPLC)
RTECS	AU6520000
Solubility	Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions can be stored at -20°C for up to 3 months.
Handling	Solutions can be stored at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

New Guanidine Alkaloids Batzelladines O and P from the Marine Sponge Monanchora pulchra Induce Apoptosis and Autophagy in Prostate Cancer Cells: S.A. Dyshlovoy, et al.; Mar. Drugs 20, 738 (2022), Abstract
Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner: C.L. Yu, et al.; Cell Death Dis. 10, 418 (2019), Abstract — Full Text
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract — Full Text
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells: Iachettini, S., Trisciuoglio, D., et al.; Cell Death Dis. 9, 996 (2018), Abstract
Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts: M. Kato, et al.; Arthritis Rheumatol. 66, 40 (2014), Application(s): IF, WB, IHC, Flow, Abstract
Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer: Del Bufalo, D., Desideri, M., et al.; Mol. Cancer 13, 230 (2014), Abstract
The thiazole derivative CPTH6 impairs autophagy: Y. Ragazzoni, et al.; Cell Death Dis. 4, e524 (2013), Application(s): IF, WB, Electron Microscopy, Abstract — Full Text
Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene: C. Guido, et al.; Cell Cycle 11, 2911 (2012), Application(s): WB, ChIP & EMSA Assays, Abstract — Full Text
Internalized gap junctions are degraded by autophagy: Fong, J. T., Kells, R. M., et al.; Autophagy 8, 794 (2012), Abstract
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III of phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem. 285, 10850 (2010), Abstract

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3-Methyladenine

BML-AP502

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Handling & Storage

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