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3-Aminobenzamide

ALX-270-044

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PARP inhibitor

Inhibits endogenous poly-ADP-ribosyltransferases often present in membrane preparations with minimal effect of bacterial toxin mediated ADP-ribosylation. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells. Protects cells from oxygen radical and nitric oxide toxicity. Inhibits stress-induced apoptosis.

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Product Details

Alternative Name	3-AB
Appearance	White to tan powder.
CAS	3544-24-9
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₇H₈N₂O
MW	136.2
Purity	≥97% (GC)
RTECS	CU8992000
Solubility	Soluble in DMSO or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Cell culture, Abstract — Full Text
Genistein induces apoptotic cell death associated with inhibition of the NF-κB pathway in adult T-cell leukemia cells: M. Yamasaki, et al.; Cell. Biol. Int. 37, 742 (2013), Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents: A. Pogrebniak, et al.; Eur. J. Med. Res. 11, 313 (2006), Abstract
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC 219, 502 (1996), Abstract
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem. 270, 11176 (1995), Abstract
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC 207, 715 (1995), Abstract
Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis: C. Nosseri, et al.; Exp. Cell Res. 212, 367 (1994), Abstract
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC 199, 1250 (1994), Abstract
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC 199, 525 (1994), Abstract

Last modified: May 29, 2024

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3-Aminobenzamide

ALX-270-044

Product Details

Handling & Storage

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