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(2R,4R)-APDC

ALX-550-178

14 citations

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mGluR agonist

Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system.

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Product Details

Alternative Name	LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
Appearance	Off-white powder.
CAS	169209-63-6
Couple Target	Metabotropic glutamate receptor
Couple Type	Activator, Ligand
Formula	C₆H₁₀N₂O₄
MW	174.2
Purity	≥98% (HPLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Activation of NLRP3 Inflammasome Complexes by Beta-Tricalcium Phosphate Particles and Stimulation of Immune Cell Migration in vivo: K. Maruyama, et al.; J. Innate Immunol. 14, 207 (2022), Abstract
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes: Freeman, L., Guo, H., et al.; J. Exp. Med. 214, 1351 (2017), Abstract
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection: Segovia, J., Sabbah, A., et al.; PLoS One 7, e29695 (2012), Abstract
Gamma-secretase gene mutations in familial acne inversa: B. Wang, et al.; Science 330, 1065 (2010), Abstract
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence: O. Gross, et al.; Nature 459, 433 (2009), Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract
Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex: C.J. Beaver, et al.; J. Neurophysiol. 82, 86 (1999), Abstract
Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats: P.J. Atwell, et al.; Brain Res. 787, 286 (1998), Abstract
Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate: T.E. Salt & J.P. Turner; Exp. Brain Res. 121, 181 (1998), Abstract
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death: G. Battaglia, et al.; Eur. J. Pharmacol. 356, 271 (1998), Abstract

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(2R,4R)-APDC

ALX-550-178

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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