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27-Hydroxycholesterol

ENZ-CHM102

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Cholesterol metabolite linked to breast cancer, neurodegenerative disease, and metabolism

27-Hydroxycholesterol (27-HC) is a metabolite resulting from the action of sterol 27-Hydroxylase on cholesterol. It is an endogenous selective estrogen receptor modulator and ligand for the liver X receptor (LXR). 27-Hydroxycholesterol plays a role in Alzheimer’s disease, oxidative stress, metabolism, cell-signaling, and heart disease.

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Product Details

Alternative Name	5,25R-Cholesten-3β,26-diol, (25R)-26-Hydroxycholesterol
Appearance	White solid.
CAS	20380-11-4
Formula	C₂₇H₄₆O₂
MW	402.7
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (up to 10 mg/ml with warming) or in ethanol (up to 10 mg/ml). Insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable, as supplied, for 2 years. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate: V. S. Nunes, et al.; Clin. Chim. Acta. 433, 169 (2014), Abstract
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine: P. Gamba, et al.; Aging Cell 13, 561 (2014), Abstract
27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes: S. M. Kim, et al.; Toxicol. Appl. Pharmacol. 274, 462 (2014), Abstract
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology: E. R. Nelson, et al.; Science 342, 1094 (2013), Abstract
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth: Q. Wu, et al.; Cell Rep. 5, 637 (2013), Abstract — Full Text
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages: S. M. Kim, et al.; Biochem. Biophys. Res. Commun. 430, 454 (2013), Abstract
Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy: J. E. Rossou, et al.; Circulation 126, 1577 (2012), Abstract — Full Text
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer’s patients with the Swedish APP 670/671 mutation: M. Shafaati, et al.; J. Lipid Res. 52, 1004 (2011), Abstract — Full Text
Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism: R. Karuna, et al.; Atherosclerosis 214, 448 (2011), Abstract
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain: M. Heverin, et al.; J. Lipid Res. 46, 1047 (2005), Abstract — Full Text

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27-Hydroxycholesterol

ENZ-CHM102

Product Details

Handling & Storage

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