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25-Hydroxyvitamin D3

BML-DM100

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Precursor to 1α,25-dihydroxyvitamin D3

Ultra-high purity
Key indicator of vitamin D levels

25-Hydroxyvitamin D3 is an Intermediate in the biosynthesis of 1α,25-dihydroxyvitamin D₃ and a major circulating metabolite of vitamin D₃. Plasma or serum levels of 25-hydroxyvitamin D3 can be determined by ELISA (Prod. No. ADI-900-215) and used as indicators of the vitamin D status of an individual.

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Product Details

Alternative Name	Calcifediol, 25-Hydroxycholecalciferol
Appearance	White to off-white crystalline solid.
CAS	19356-17-3
Couple Target	Vitamin D receptor
Couple Type	Ligand
Formula	C₂₇H₄₄O₂
Identity	Identity determined by MS and NMR.
MW	400.6
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and oxygen.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite: A. Mendoza, et al.; Cell Chem. Biol. 29, 660 (2022), Abstract
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells: D. Chauss, et al.; Nat. Immunol. 23, 62 (2022), Abstract
Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior: V. Sarangthem, et al.; Biomedicines 10, 1151 (2022), Abstract
Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets: F.A.H. Al-Jaberi, et al.; Front. Immunol. 12, 684015 (2021), Abstract — Full Text
Vitamin D promotes trophoblast cell induced separation of vascular smooth muscle cells in vascular remodeling via induction of G-CSF: J.Y. Zhang, et al.; Front Cell Dev Biol 8, 601043 (2020), Abstract — Full Text
CD55 regulates bone mass in mice by modulating RANKL-mediated Rac signaling and osteoclast function: B. Shin, et al.; J. Bone Miner. Res. 35, 130 (2020), Abstract — Full Text
Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis: B.D. Bryson, et al.; Nat. Commun. 10, 2329 (2019), Abstract — Full Text
Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN: K. Zavala, et al.; PLoS Negl. Trop. Dis. 12, e0006815 (2018), Abstract — Full Text
Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion: A.K.O. Rode, et al.; Front. Immunol. 8, 656 (2017), Abstract — Full Text
Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions: M. Mihajlovic, et al.; Int. J. Mol. Sci. 18, 2531 (2017), Abstract — Full Text